The Murthy Lab, along with collaborators in Hye Young Lee’s lab at the University of Texas, San Antonio, has published the paper “Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours” in Nature Biomedical Engineering. In the paper, we demonstrate that our previously developed CRISPR-Gold gene editing delivery system may be effectively delivered into brain cells of mice via intracranial injection, and subsequently rescue mice from fragile X syndrome, a genetic autism spectrum disorder.
This paper has received significant news coverage. A selection of news articles about this paper can be found below:
The Telegraph: Autism traits could be ‘edited’ out genetic trial suggests
Science Daily: CRISPR editing reduces repetitive behavior in mice with a form of autism
Newsweek: THE END OF AUTISM? CRISPR CAN EDIT OUT AUTISM TRAITS, SCIENTISTS SAY
Popular Science: CRISPR could use gold nanoparticles to edit your brain
The Daily Californian: Study finds CRISPR-Cas9 technology can lessen autism symptoms in mice
SFGate: Study: CRISPR gene editing tech reduced autism symptoms in mice