Murthy Lab at UC Berkeley

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Publications

2024

  1. Kai Chen, Hesong Han, Sheng Zhao et al.(2024), Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein, Nature Biotechnology, 10.1038/s41587-024-02437-3. [link]
  2. Sheng Zhao, Kewa Gao, Hesong Han, Michael Stenzel, Boyan Yin, Hengyue Song.et al., (2024) Acid-degradable lipid nanoparticles enhance delivery of mRNA.  Nature Nanotechnology, 10.1038/s41565-024-01765-4.  [link]
  3. EA Woodward, E Wang, C Wallis, R Sharma, AWJ Tie, N Murthy, et al. (2024) Protocol for Delivery of CRISPR/dCas9 Systems for Epigenetic Editing into Solid Tumors Using Lipid Nanoparticles Encapsulating RNA. Epigenome Editing: Methods and Protocols,pp 267–287.  [link]
  4. K Aran et al. (2024) Active Agent Delivery Devices and Methods of Using the same.US Patent App. 18/525,612. [link]
  5. K Takemiya, S Wang, Y Liu, N Murthy, MM Goodman, WR Taylor, (2024) Isothermal titration calorimetry analysis of the binding between the maltodextrin binding protein malE of Staphylococcus aureus with maltodextrins of various lengths. Biochemical and Biophysical Research Communications, 10.1016/j.bbrc.2023.149467. [link]
  6. GN Ramadoss, SJ Namaganda, JR Hamilton, et al. (2024), Neuronal DNA repair reveals strategies to influence CRISPR editing outcomes. bioRxiv. [link]

2023

  1. Jan Tuma, Yu-Ju Chen, Michael G. Collins, Abhik Paul, Jie Li, Hesong Han, Rohit Sharma, Niren Murthy, Hye Young Lee, (2023) Lipid nanoparticles deliver mRNA to brain after intracerebral injection. Biochemistry. [link]
  2. Qi, Y.L., Li, Y.Z., Tan, M.J., Yuan, F.F., Murthy, N., Duan, Y.T., Zhu, H.L., Yang, S.Y.(2023) Recent advances in organic near-infrared ratiometric small-molecule fluorescent probes. Coordination Chemistry Reviews., 486, 215130. [link]
  3. Gao, K., Li, J., Song, H., Han, H., Wang, Y., Yin, B., Farmer, D.L., Murthy, N. and Wang, A. (2023). In utero delivery of mRNA to the heart, diaphragm and muscle with lipid nanoparticles. Bioactive Materials, 25, 387-398 [link]
  4. Hansol, K., Jang, S.H., Zhao,S., Murthy, N. (2023). Development of Streptolysin O Toxin Based Delivery System for Enhanced Intracellular Delivery of siRNA. Korean Biotechnology Society, 420-420.[link]
  5. Sellers, D. L., Lee, K., Murthy, N., & Pun, S. H. (2023). TAxI-peptide targeted Cas12a ribonuclease protein nanoformulations increase genome editing in hippocampal neurons. Journal of Controlled Release, 354, 188-195.[link]
  6. Bajaj, T.,Wehri, E., Suryawanshi, R.K.,  King, E.,  Pardeshi, K.S., Behrouzi,K., Khodabakhshi, Z., Schulze-Gahmen,U., Kumar, G. R., Mofrad, M.RK., Nomura, D.K., Ott,M., Schaletzky,J., Murthy, N. (2023) Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication. RSC Advances,13(26) 17667-17677 [link]
  7. Han, H., Gracia, A. V., Røise, J. J., Boike, L., Leon, K., Schulze-Gahmen, U., Stentzel, M.R., Bajaj, T., Chen, D., Li, I.C. He,M., Behrouzi,K., Zahra Khodabakhshi,Z., Nomura,D.K.,  Mofrad, M.RK., Kumar,G.R., Ott,M., & Murthy, N. (2023). A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication. RSC advances, 13(16), 10636-10641.[link]

2022

  1. Li, J., Tuma, J., Han, H., Kim, H., Wilson, R. C., Lee, H. Y., & Murthy, N. (2022). The coiled‐coil forming peptide (KVSALKE) 5 is a cell penetrating peptide that enhances the intracellular delivery of proteins. Advanced Healthcare Materials., 11(9), 2102118.[link]
  2. Hadaczek, P., Manohar, B., Clark, A., Travis, M., Sharma, R., Zhao, S.,Van Laar, V., Murthy, N., Wilson, R. and Bankiewicz, K. (2022). Development of a Monoparticle-Based Gene Editing Technology for Neurological Applications. Molecular Therapy (Vol. 30, No. 4, pp. 283-283).CELL PRESS. [link]
  3. Gao, K., Li, J., Song, H., Han, H., Wang, Y., Yin, B., Farmer, D.L., Murthy, N. and Wang, A. (2022). Non-viral gene editing in utero with lipid nanoparticles complexed to mRNA. bioRxiv, 2022-10.[link]
  4. Espinoza, E.M., Røise, J.J., He, M., Li, I-C., Agatep, A.K., Udenyi, P., Han, H., Jackson, N., Kerr, D.L., Chen, D., Stentzel, M.R., Ruan, E., Riley, L. & Murthy, N. (2022) A self-immolative linker that releases thiols detects penicillin amidase and nitroreductase with high sensitivity via absorption spectroscopy Chemical Communications, 58(19), 3166-3169 [link]
  5. Holt, B.A., Tuttle, M., Xu, Y., Su, M., Røise, J.J., Wang, X., Murthy, N. & Kwong, G.A. (2022) Dimensionless parameter predicts bacterial prodrug success Molecular Systems Biology, 18: e10496. [link]

2021

  1. Røise, J.J.*, Han, H.*, Li, J., Kerr, D.L., Taing, C., Behrouzi, K., He, M., Ruan, E., Chan, L.Y., Espinoza, E.M., Reinhard, S., Thakker, K., Kwon, J., Mofrad, M.R.K., & Murthy, N. (2021). Acid-Sensitive Surfactants Enhance the Delivery of Nucleic Acids. Molecular Pharmaceutics,19(1), 67-79. [link]
  2. Li, J., Tuma, J., Han, H., Kim, H., Wilson, R., Lee, H.Y. & Murthy, N. (2021). The Coiled‐Coil Forming Peptide (KVSALKE) 5 is A Cell Penetrating Peptide that Enhances the Intracellular Delivery of Proteins. Advanced Healthcare Materials, p.2102118. [link]
  3. Biering, S.B., Van Dis, E., Wehri, E., Yamashiro, L.H., Nguyenla, X., Dugast-Darzacq, C., Graham, T.G., Stroumza, J.R., Golovkine, G.R., Roberts, A.W., Fines, D.M., Spradlin, J.N., Ward, C.C., Bajaj, T., Dovala, D., Schulze-Gamen, U., Bajaj, R., Fox, D.M., Ott, M., Murthy, N., Nomura, D., Schaletzky, J. & Stanley, S.A. (2021). Screening a library of FDA-approved and bioactive compounds for antiviral activity against SARS-CoV-2. ACS infectious diseases, 7(8), pp.2337-2351. [link]
  4. Saha K., Sontheimer E.J., Brooks P.J., Dwinell M.R., Gersbach C.A., Liu D.R., Murray S.A., Tsai S.Q., Wilson R.C., Anderson D.G., Asokan A., Banfield J.F., Bankiewicz K.S., Bao G., Bulte J.W.M., Bursac N., Campbell J.M., Carlson D.F., Chaikof E.L., Chen Z.Y., Cheng R.H., Clark K.J., Curiel D.T., Dahlman J.E., Deverman B.E., Dickinson M.E., Doudna J.A., Ekker S.C., Emborg M.E., Feng G., Freedman B.S., Gamm D.M., Gao G., Ghiran I.C., Glazer P.M., Gong S., Heaney J.D., Hennebold J.D., Hinson J.T., Khvorova A., Kiani S., Lagor W.R., Lam K.S., Leong K.W., Levine J.E., Lewis J.A., Lutz C.M., Ly D.H., Maragh S., McCray P.B. Jr, McDevitt T.C., Mirochnitchenko O., Morizane R., Murthy N., Prather R.S., Ronald J.A., Roy S., Roy S., Sabbisetti V., Saltzman W.M., Santangelo P.J., Segal D.J., Shimoyama M., Skala M.C., Tarantal A.F., Tilton J.C., Truskey G.A., Vandsburger M., Watts J.K., Wells K.D., Wolfe S.A., Xu Q., Xue W., Yi G., Zhou J.; SCGE Consortium (2021) The NIH somatic cell genome editing program Nature (2021) Apr;592(7853):195-204. [link]
  5. Takemiya, K., Røise, J.J., He, M., Taing, C., Rodriguez, A.G., Murthy, N., Goodman, M.M. & Taylor, W.R. (2021). Maltohexaose-indocyanine green (MH-ICG) for near infrared imaging of endocarditis. PLoS ONE 16(3): e0247673 [link]
  6. Yang, X., Ren, H., Zhang, H., Liu, G., Jiang, Z., Qiu, Q., Yu, C., Murthy, N., Zhao, K., Lovell, J.F. & Zhang, Y. (2021). Antibiotic Cross-linked Micelles with Reduced Toxicity for Multidrug-Resistant Bacterial Sepsis Treatment. ACS Applied Materials & Interfaces, 13(8), 9630-9642. [link]
  7. Jackson, N., Borges, C.A., Tarlton, N.J., Resendez, A., Milton, A.K., de Boer, T.R., Butcher, C.R., Murthy, N. & Riley, L.W., (2021). A rapid, antibiotic susceptibility test for multi-drug resistant, Gram-negative bacterial uropathogens using the biochemical assay, DETECT. Journal of Microbiological Methods,  182, 106160. [link]

2020

  1. Espinoza, E.M.*, Røise, J.J.*, Li, I., Das, R., & Murthy, N. (2020). Advances in Reactive Oxygen Species (ROS) Imaging. Journal of Nuclear Medicine, Just Accepted. DOI:10.2967/jnumed.120.245415.
  2. Reinhard, S.*, Han, H.*, Tuma, J., Røise, J.J., Li, I., Li, J., Lee, H. Y. & Murthy, N. (2020). A pH-sensitive eosin-block copolymer delivers proteins intracellularly. Chemical Communications, Just accepted. DOI:10.1039/D0CC05165A.
  3. Li, J., Røise, J. J.*, He, M.*, Das, R. & Murthy, N. (2020). Non-viral strategies for delivering genome editing enzymes. Advanced Drug Delivery Reviews, In Press. [link]
  4. Tarlton, N.J., Petrovic, D.F., Frazee, B.W., Borges, C.A., Pham, E.M., Milton, A.K., Jackson, N., deBoer, T.R., Murthy, N. and Riley, L.W., (2020). A Dual Enzyme-Based Biochemical Test Rapidly Detects Third-Generation Cephalosporin-Resistant CTX-M-Producing Uropathogens in Clinical Urine Samples. Microbial Drug Resistance, Just Accepted [link]
  5. He, M.*, Li, J.*, Han, H., Araújo, C., Neiman, G., Røise, J.J., Hadaczek, P., Mendonsa, R., Holm, V., Wilson, R. C., Bankiewicz, K.,  Zhang, Y., Sadlowski, C. M., Healy, K., Riley, L. & Murthy, N. (2020). A traceless linker for aliphatic amines that rapidly and quantitatively fragments after reduction Chemical Science, 11(33), 8973-8980. [link]
  6. van Haasteren, J., Li, J., Scheideler, O. J., Murthy, N. & Schaffer, D. V. (2020). The delivery challenge: fulfilling the promise of therapeutic genome editing. Nature Biotechnology, 38, 845–855. [link]
  7. Maity, S., Wang, X., Das, S., He, M., Riley, L. W., & Murthy, N. (2020). A cephalosporin–chemiluminescent conjugate increases beta-lactamase detection sensitivity by four orders of magnitude. Chemical Communications, 56(24), 3516-3519. DOI: 10.1039/C9CC09498A
  8. Adams, J. D., Røise, J. J., Lee, D. S., & Murthy, N. (2020). The methionase chain reaction: an enzyme-based autocatalytic amplification system for the detection of thiols. Chemical Communications, 56(21), 3175-3178. [link]

2019

  1. Li, J.*, Røise, J. J.*, Zhang, J.*, Yang, J., Kerr, L., Han, H., & Murthy, N. (2019). A novel fluorescent surfactant enhances the delivery of the Cas9 ribonucleoprotein and enables the identification of edited cells. Chemical Communications, 55, 4562-4565.[link]Graphical abstract: A novel fluorescent surfactant enhances the delivery of the Cas9 ribonucleoprotein and enables the identification of edited cells
  2. Hajian, R., Balderston, S., Tran, T., deBoer, T., Etienne, J., Sandhu, M., Wauford, N.A., Chung, J-Y., Nokes, J., Athaiya, M., Paredes, J., Peytavi, R., Goldsmith, B., Murthy, N., Conboy, I.M. and Aran, K. (2019) Detection of unamplified target genes via CRISPR-Cas9 immobilized on a graphene field-effect transistor. Nature Biomedical Engineering, 3, 427-437. [link]
  3. Jackson, N., Wu, T., Adams-Sapper, S., Satoorian, T., Geisberg, M., Murthy, N., Lee, L. and Riley, L.W., (2019) A multiplexed, indirect enzyme-linked immunoassay for the detection and differentiation of E. coli from other Enterobacteriaceae and P. aeruginosa from other glucose non-fermenters. Journal of Microbiological Methods, 158, 52-58. [link]
  4. Takemiya, K., Ning, X., Seo, W., Wang, X., Mohammad, R., Joseph, G., Titterington, J. S., Kraft, C. S., Nye, J. A., Murthy, N., Goodman M. M., and Taylor, W.R., (2019) Novel PET and Near Infrared Imaging Probes for the Specific Detection of Bacterial Infections Associated With Cardiac Devices. JACC: Cardiovascular Imaging, 12, 875-866. [link]

2018

  1. Rouet, R., de Oñate, L., Li, J., Murthy, N. and Wilson, R.C., (2018) Engineering CRISPR-Cas9 RNA–Protein Complexes for Improved Function and Delivery. The CRISPR Journal, 1(6), pp.367-378. [link]
  2. Conboy, I., Murthy, N., Etienne, J. and Robinson, Z., (2018) Making gene editing a therapeutic reality. F1000Research, 7. [link]
  3. Park, H.M., Liu, H., Wu, J., Chong, A., Mackley, V., Fellmann, C., Rao, A., Jiang, F., Chu, H., Murthy, N. and Lee, K., (2018). Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo. Nature communications, 9(1), p.3313. [link]
  4. Li, C., Wang, Y., Du, Y., Qian, M., Jiang, H., Wang, J., Murthy, N. and Huang, R., (2018). Side effects-avoided theranostics achieved by biodegradable magnetic silica-sealed mesoporous polymer-drug with ultralow leakage. Biomaterials [link]
  5. Sadlowski, C.M., Balderston, S., Sandhu, M., Hajian, R., Liu, C., Tran, T.T., Conboy, M.J., Paredes, J., Murthy, N., Conboy, I.M. and Aran, K., (2018). Graphene-based biosensor for on-chip detection of Bio-orthogonally Labeled Proteins to Identify the Circulating Biomarkers of Aging during Heterochronic Parabiosis. Lab on a Chip [link]
  6. DeBoer, T., Tarlton, N., Yamaji, R., Adams-Sapper, S., Wu, T., Maity, S., Vegesna, G., Sadlowski, C., DePaola, P. and Riley, L.W., Murthy, N. (2018). An enzyme‐mediated amplification strategy enables detection of β‐lactamase activity directly in unprocessed clinical samples for phenotypic detection of β‐lactam resistance. ChemBioChem [link]
  7. Lee, B., Lee, K., Panda, S., Gonzales-Rojas, R., Chong, A., Bugay, V., Park, H.M., Brenner, R., Murthy, N. and Lee, H.Y (2018). Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours. Nature Biomedical Engineering, 1. [link] Mentioned in: Forbes, Berkeley News, Newsweek.
  8. Zhang, J., Yang, S.J., Gonzalez, F., Yang, J., Zhang, Y., He, M., Shastri, N. and Murthy, N. (2018). A peptide-based fluorescent probe images ERAAP activity in cells and in high throughput assays. Chemical Communications. [link]
  9. Sadlowski, C.M.*, Park, B.*, Araújo, C., Das, S., Kerr, L., He, M., Han, H., Riley, L. and Murthy, N. (2018). Nitro Sulfonyl Fluorides are a new pharmacophore for the development of antibiotics. Molecular Systems Design & Engineering. [link]
  10. Wang, X., Borges, C. A., Ning, X., Rafi, M., Zhang, J., Park, B., Takemiya, K., Sterzo, C.L., Taylor, W.R., Riley, L.W. & Murthy, N. (2018). A trimethoprim conjugate of thiomaltose has enhanced antibacterial efficacy in vivo. Bioconjugate chemistry, ASAP. [link]
  11. Zhang, Y., Røise, J. J., Lee, K., Li, J., & Murthy, N. (2018). Recent developments in intracellular protein delivery. Current opinion in biotechnology, 52, 25-31. [link]
  12. Deboer, T. R., Wauford, N., Chung, J. Y., Torres Perez, M. S., & Murthy, N. (2018). A cleavage-responsive stem-loop hairpin for assaying guide RNA activity. ACS chemical biology, 13(2), 461-466. [link]

2017

  1. Lee K, Conboy M, Park H, Jiang F, Kim H, Dewitt M, Mackley V, Chang K, Rao A, Skinner C, Shobha T, Mehdipour M, Liu H, Huang W, Lan F, Bray N, Li S, Corn J, Kataoka K, Doudna J, Conboy I*, Murthy N*. “Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homologous directed DNA repair”.  Nature Biomedical Engineering.  2017 In Press. [link]    Highlight by Francis Collins, the Director of the NIH blogs; U.C. Berkeley website; Fierce Biotech; Genetic Engineering and Biotechnology News and The Scientist.
  2. Kiana Aran*, Marc Chooljian, Jacobo Paredes, Mohammad Rafi, Kunwoo Lee, Allison Y. Kim, Jeanny An, Jennifer F. Yau, Helen Chum, Irina Conboy, Niren Murthy*, Dorian Liepmann*. An oral microjet vaccination system elicits antibody production in rabbits. Science Translational Medicine. 2017, Vol. 9, Issue 380, aaf6413 (abstract).     Reported on news:  “Needle-free, painless vaccinations may become a reality thanks to MucoJet“”Device developed for painless vaccine delivery“
  3. Xuefeng Qiu, Benjamin Li-Ping Lee, Xinghai Ning, Niren Murthy, Nianguo Dong, Song Li. End-Point Immobilization of Heparin on Plasma-Treated Surface of Electrospun Polycarbonate-Urethane Vascular Graft. Acta Biomater. 51 (2017) 138–147 (abstract)
  4. Corinne M. Sadlowski, Santanu Maity, Kousik Kundu and  Niren Murthy*. Hydrocyanines: a versatile family of probes for imaging radical oxidants in vitro and in vivo. Mol. Syst. Des. Eng., 2017, Advance Article (abstract)
  5. Kunwoo Lee,* Vanessa A Mackley, Anirudh Rao, Anthony T Chong, Mark A Dewitt, Jacob E Corn, Niren Murthy*. Synthetically modified guide RNA and donor DNA are a versatile platform for CRISPR-Cas9 engineering. eLife.  2017; 6: e25312 (abstract)
  6. Chengyi Li, Min Qian, Shanshan Wang, Huilin Jiang, Yilin Du, Jianxin Wang, Weiyue Lu, Niren Murthy, Rongqin Huang*.  Aptavalve-gated mesoporous carbon nanospheres image cellular mucin and provide on-demand targeted drug delivery. Theranostics. (2017) 7(13):3319-3325.
  7. Santanu Maity,  Subhamoy Das,  Corinne M. Sadlowski,  Jingtuo Zhang,  Giri K. Vegesna  and  Niren Murthy*.  Thiophene bridged hydrocyanine- a new fluorogenic ROS probe. Chemical Communications. (2017) 53(73):10184-10187.
  8. Santanu Maity,  Corinne M. Sadlowski,  Jung-Ming George Lin,  Che-Hong Chen,  Li-Hua Peng,  Eun-Soo Lee,  Giri K. Vegesna,  Charles Lee,  Se-Hwa Kim,  Daria Mochly-Rosen,  Sanjay Kumar  and  Niren Murthy*.  Thiophene bridged aldehydes (TBAs) image ALDH activity in cells via modulation of intramolecular charge transfer. Chemical Science. (2017) 8, 7143-7151.

2016

  1. Todd A. Duncombe, Chi-Chih Kang, Santanu Maity, Toby M. Ward, Mark D. Pegram, Niren Murthy , and Amy E. Herr. Hydrogel Pore-Size Modulation for Enhanced Single-Cell Western Blotting. Adv. Mater. (2016), 28, 327–334 (abstract)

2015

  1. Maity, S; Choudhary, P; Manjunath, M; Kulkarni, A; Murthy, N. A biodegradable adamantane polymer with ketal linkages in its backbone for gene therapy. Chem. Commun. (2015), 51(88), 15956-15959. (abstract)
  2. Maxwell, JT; Somasuntharam, I; Gray, WD; Shen, M; Singer, JM; Wang, B; Saafir, T; Crawford, BH; Jiang, R; Murthy, N; Davis, ME; Wagner, MB. Bioactive nanoparticles improve calcium handling in failing cardiac myocytes. Nanomedicine (2015), 10(22), 3343-3357. (abstract)
  3. Lee, K; Lingampalli, N; Pisano, AP; Murthy, N; So, H. Physical Delivery of Macromolecules using High-Aspect Ratio Nanostructured Materials. ACS Appl. Mater. Interfaces (2015), 7(42), 23387-23397. (abstract)
  4. Rape, AD; Zibinsky, M; Murthy, N; Kumar, S. A synthetic hydrogel for the high-throughput study of cell-ECM interactions. Nat. Commun. (2015), 6, 8129 (abstract)
  5. Prunty, MC; Aung, MH; Hanif, AM; Allen, RS; Chrenek, MA; Boatright, JH; Thule, PM; Kundu, K; Murthy, N; Pardue, M. In Vivo Imaging of Retinal Oxidative Stress Using a Reactive Oxygen Species-Activated Fluorescent Probe. Invest Ophthalmol Vis Sci. (2015), 56(10), 8562-8570. (abstract)
  6. Lee, K; Rafi, M; Wang, XJ; Aran, K; Feng, XL; Lo Sterzo, C; Tang, R; Lingampalli, N; Kim, HJ; Murthy, N. In vivo delivery of transcription factors with multifunctional oligonucleotides. Nature Mater. (2015), 14(7), 701-706. (abstract)
  7. Aran, K; Parades, J; Rafi, M; Yau, JF; Acharya, AP; Zibinsky, M; Liepmann, D; Murthy, N. Stimuli-Responsive Electrodes Detect Oxidative Stress and Liver Injury. Adv. Mater. (2015), 27(8), 1433-1436. (abstract) (journal frontispiece)
  8. Huang, TH; Ning, XH; Wang, XJ; Murthy, N; Tzeng, YL; Dickson, RM. Rapid Cytometric Antibiotic Susceptibility Testing Utilizing Adaptive Multidimensional Statistical Metrics. Anal. Chem. (2015), 87(3), 1941-1949. (abstract)
  9. (9)   Acharya, AP; Sen, P; Aran, K; Gardner, AB; Rafi, M; Dean, D; Murthy, N. A Turn-Off Fluorescent Substrate for Horseradish Peroxidase Improves the Sensitivity of ELISAs. J. Polym. Sci. A Polym. Chem. (2015), 53(2), 206-210. (abstract)
  10. Lee, K; Yu, PZ; Lingampalli, N; Kim, YJ; Tang, R; Murthy, N. Peptide-enhanced mRNA transfection in cultured mouse cardiac fibroblasts and direct reprogramming towards cardiomyocyte-like cells. Int. J. Nanomedicine (2015), 10, 1841-1854. (abstract)
  11. Suri, S; Lehman, SM; Selvam, S; Reddie, K; Maity, S; Murthy, N; Garcia, AJ. In vivo fluorescence imaging of biomaterial-associated inflammation and infection in a minimally invasive manner. J. Biomed. Mater. Res. A (2015), 103(1), 76-83. (abstract)

2014

  1. So H, Lee K, Seo YH, Murthy N, Pisano AP. “Hierarchical silicon nanospikes membrane for rapid and high-throughput mechanical cell lysis”. ACS Appl Mater Interfaces. (2014), 6(10), 6993-7. (abstract)
  2. Burton LJ, Barnett P, Smith B, Arnold RS, Hudson T, Kundu K, Murthy N, Odero-Marah VA. “Muscadine grape skin extract reverts snail-mediated epithelial mesenchymal transition via superoxide species in human prostate cancer cells”. BMC Complement Altern Med. (2014), 14, 97. (pdf)
  3. Suri S, Lehman SM, Selvam S, Reddie K, Maity S, Murthy N, Garcia AJ. “In vivo fluorescence imaging of biomaterial-associated inflammation and infection in a minimally invasive manner”. J Biomed Mater Res A. (2014) In Press. (pdf)
  4. Khan RS, Martinez MD, Sy JC, Pendergrass KD, Che PL, Brown ME, Cabigas EB, Dasari M, Murthy N, Davis ME. “Targeting extracellular DNA to deliver IGF-1 to the injured heart”. Sci Rep. (2014), 4, 4257. (pdf)
  5. So H, Lee K, Murthy N, Pisano AP. All-in-one nanowire-decorated multifunctional membrane for rapid cell lysis and direct DNA isolation. ACS Appl. Mater. Interfaces. (2014), 6(23), 20693-20699 (abstract)
  6. Wang X, Murthy N. Bacterial imaging comes of age. Sci. Transl. Med. (2014), 6(259), 259fs43. (abstract)
  7. Ning X, Seo W, Lee S, Takemiya K, Rafi M, Feng X, Weiss D, Wang X, Williams L, Camp VM, Eugene M, Taylor WR, Goodman M, Murthy N. PET imaging of bacterial infections with fluorine-18-labeled maltohexaose. Angew. Chem. Int. Ed. Engl. (2014), 53(51), 14096-101. (abstract)
  8. Hermann CD, Wilson DS, Lawrence KA, Ning X, Olivares-Navarrete R, Williams JK, Guldberg RE, Murthy N, Schwartz Z, Boyan BD. Rapidly polymerizing injectable click hydrogel therapy to delay bone growth in a murine re-synostosis model. Biomaterials. (2014), 35(36), 9698-9708. (abstract)
  9. Acharya AP, Rafi M, Woods EC, Gardner AB, Murthy N. Metabolic engineering of lactate dehydrogenase rescues mice from acidosis. Sci Rep. (2014), 4, 5189. (abstract)

2013

  1. Cowan EA, Taylor JL, Oldham CD, Dasari M, Doyle D, Murthy N, May SW. “Cellular antioxidant activity of phenylaminoethyl selenides as monitored by chemiluminescence of peroxalate nanoparticles and by reduction of lipopolysaccharide-induced oxidative stress”. Enzyme Microb Technol. (2013), 53(6-7), 373-7. (abstract)
  2. Acharya AP, Nafisi PM, Gardner A, Mackay JL, Kundu K, Kumar S, Murthy N. “A fluorescent peroxidase probe increases the sensitivity of commercial ELISAs by two orders of magnitude”. Chem Commun (Camb). (2013), 49(88), 10379-81. (pdf)
  3. Somasuntharam I, Boopathy AV, Khan RS, Martinez MD, Brown ME, Murthy N, Davis ME. “Delivery of Nox2-NADPH oxidase siRNA with polyketal nanoparticles for improving cardiac function following myocardial infarction”. Biomaterials. (2013), 34(31), 7790-8. (abstract)
  4. Sohn, Y. D.; Somasuntharam, I.; Che, P. L.; Jayswal, R.; Murthy, N.; Davis, M. E.; Yoon, Y. S., Induction of pluripotency in bone marrow mononuclear cells via polyketal nanoparticle-mediated delivery of mature microRNAs. Biomaterials (2013), 34 (17), 4235-41. (pdf)
  5. Leoni, G.; Alam, A.; Neumann, P. A.; Lambeth, J. D.; Cheng, G.; McCoy, J.; Hilgarth, R. S.; Kundu, K.; Murthy, N.; Kusters, D.; Reutelingsperger, C.; Perretti, M.; Parkos, C. A.; Neish, A. S.; Nusrat, A., Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. The Journal of Clinical Investigation (2013), 123 (1), 443-54. (pdf)
  6. Dasari, M.; Acharya, A. P.; Kim, D.; Lee, S.; Rhea, J.; Molinaro, R.; Murthy, N., H-gemcitabine: a new gemcitabine prodrug for treating cancer. Bioconjugate Chemistry (2013), 24 (1), 4-8. (pdf)

2012

  1. Whitmire, R. E.; Wilson, D. S.; Singh, A.; Levenston, M. E.; Murthy, N.; Garcia, A. J., Self-assembling nanoparticles for intra-articular delivery of anti-inflammatory proteins. Biomaterials (2012), 33 (30), 7665-75. (pdf)
  2. Perng JK, Lee S, Kundu K, Caskey CF, Knight SF, Satir S, Ferrara KW Taylor WR, Degertekin FL,  Sorescu D, Murthy N.  “Ultrasound Imaging of Oxidative Stress In Vivo with Chemically Generated Gas Microbubbles”.  Annals of Biomedical Engineering.  (2012), 40(9), 2059-68. (pdf)
  3. Knight SF, Kundu K, Joseph G, Dikalov S, Weiss D, Murthy N, Taylor WR.  “Folate Receptor-Targeted Antioxidant Therapy Ameliorates Renal Ischemia-Reperfusion Injury”.  J Am Soc Nephrol.  (2012), 5, 793-800
  4. Reddie KG, Humphries WH, Bain CP, Payne CK, Kemp ML, Murthy N.  “Fluorescent Coumarin Thiols Measure Biological Redox Couples”.  Organic Letters.  (2012). 3, 680-683. (pdf)
  5. Xie L, Lin AS, Kundu K, Levenston ME, Murthy N, Guldberg RE.  “Quantitative imaging of cartilage and bone morphology, reactive oxygen species, and vascularization in a rodent model of osteoarthritis”.  Arthritis Rheum.   (2012), 64(6), 1899-1908. (pdf)
  6. Goodson P, Kumar A, Jain L, Kundu K, Murthy N, Koval M, Helms MN.  “Nadph oxidase regulates alveolar epithelial sodium channel (ENaC) activity and lung fluid balance in vivo via O2- signaling”.  Am J Physiol Lung Cell Mol Physiol.  (2012), 4, L410-L419. (pdf)
  7. Phelps EA, Enemchukwu NO, Fiore VF, Sy JC, Murthy N, Sulchek TA, Barker TH, García AJ.  “Maleimide cross-linked bioactive PEG hydrogel exhibits improved reaction kinetics and cross-linking for cell encapsulation and in situ delivery”.  Advanced Materials.   (2012), 24(1), 64-70. (pdf)

2011

  1. Ning X, Lee S, Wang Z, Kim D, Subbtlefield B, Gilbert E, Murthy N.  “Maltodextrin based imaging probes detect bacteria in vivo with high sensitivity and specificity”.  Nature Materials.  (2011), 10(8), 602-7 (pdf)
  3. Gray W, Che P, Brown M, Ning X, Murthy N, Davis M. “N-acetylglucosamine conjugated to nanoparticles enhances myocyte uptake and improves delivery of a small molecule p38 inhibitor for post-infarct healing”. J. of Cardiovasc. Trans. Res. (2011), 4(5), 631-43. (pdf)
  4. Selvam S, Kundu K, Templeman KL, Murthy N, García AJ.  “Minimally invasive, longitudinal monitoring of biomaterial-associated inflammation by fluorescence imaging”.  Biomaterials.  (2011), 32 (31), 7785-92. (pdf)
  5. Swanson PA, Kumar A, Samarin S, Vijay-Kumar M, Kundu K, Murthy N, Hansen J, Nusrat A, Neish A. “Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases”. Proc. Natl. Acad. Sci. (2011), 108(21), 8803-8808. (pdf)
  6. Kasturi SP, Skountzou I, Randy A, Koutsonanos K, Hua T, Nakaya H, Ravindran R, Stewart S, Alam M, Murthy N, Hogan RJ, Sastre A, Compans R, Pulendran B. “Synergistic TLR activation stimulates persistent germinal centers and long-lived antibody producing cells that protect against avian and swine influenza”. Nature. (2011), 470 (7335), 543-547. (pdf)

2010

  1. D. Scott Wilson, Guillaume Dalmasso,Lixin Wang, Shanthi V. Sitaraman, Didier Merlin & Niren Murthy. ” Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines” Nature Materials, (2010), 9, 923-928. (pdf)
  2. Kundu K, Knight S, Willett N, Lee S, Taylor W, Murthy N. “A Significant Improvement of the Efficacy of Radical Oxidant Probes by the Kinetic Isotope Effect”. Angewandte Chemie International (2010), 49(25), 6134-38. (pdf)
  3. Sullivan SP, Koutsonanos DG, Martin MP, Lee JW, Zarnitsyn V, Murthy N, Compans RW, Skountzou I, Prausnitz MR. “Dissolving polymer microneedle patches for influenza Vaccination”. Nature Medicine. (2010), 16, 915-20. (pdf)
  4. Tang H, Cao W, Kasturi S, Pai R, Nakaya HI, Kundu K, Murthy N, Kepler TB, Malissen B, Pulendran B. “The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling”. Nature Immunology. (2010), 11(7), 608-617. (pdf)
  5. Sy J, Phelps E, Garcia AJ, Murthy N, Davis ME. “Surface functionalization of polyketal microparticles with nitrilotriacetic acid-nickel complexes for efficient protein capture and delivery”. Biomaterials. (2010), 31(18), 4987-4994. (pdf)
  6. Fiore VF, Lofton MC, Roser-Page S, Yang SC, Roman J, Murthy N, Barker TH. “Polyketal microparticles for therapeutic delivery to the lung”. Biomaterials (2010), 31(5), 810-817. (pdf)
  7. Seshadri G, Sy J, Dikhalov S, Murthy N, Davis M. “The delivery of superoxide dismutase encapsulated in polyketal microparticles to rat myocardium and protection from myocardial ischemia-reperfusion injury“. Biomaterials (2010), 31(6), 1372-1379. (pdf)

 

2009

  1. Lee S, Yang SC, Kao CY, Pierce RH, Murthy N. “Solid polymeric microparticles enhance the delivery of siRNA in vivo”. Nucleic Acid Research (2009), 37(22), e145/1-e145/10. (pdf)Heffernan M, Murthy N. “Disulfide-crosslinked polyion micelles for delivery of protein therapeutics”. Annals of Biomedical Engineering (2009), 37(10), 1993-2002. (pdf)
  2. Lin P, Myers L, Ray L, Song S, Nasr T, Berardinelli A, Kundu K, Murthy N, Hansen J, Neish A. “Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation”. Free Radical Biology & Medicine (2009), 47(8), 1205-1211. (pdf)
  3. Dasari M, Lee D, Erigala VR, Murthy N. “Chemiluminescent PEG-PCL micelles for imaging hydrogen peroxide”. Journal of Biomaterials Research, Part A (2009) 89A (3) 561-566. (pdf)
  4. Heffernan MJ, Kasturi SP, Yang S, Pulendran B, Murthy N. “The stimulation of CD8+ T cells by dendritic cells pulsed with polyketal microparticles containing ion-paired protein antigen and poly(inosinic acid)–poly(cytidylic acid)“. Biomaterials (2009), 30 (5) 910-918. (pdf)
  5. Kundu K, Knight S, Willett N, Lee S, Taylor W, Murthy N. “Hydrocyanines: A new class of fluorescent sensors that can image reactive oxygen species in cell culture, tissue and in vivo”. Angewandte Chemie International (2009), 48 (2), 299-303. (pdf)

2008

  1. Sy J, Iyer G, Yang S, Brown M, Oh T, Dikalov S, Murthy N, Davis ME. “Sustained release of a p38-inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction”. Nature Materials. (2008), 7 (11), 863-868. (pdf)
  2. Lee D, Erigala VR, Dasari M, Yu J, Dickson RM, Murthy N. “Detection of hydrogen peroxide with chemiluminescent micelles”. International Journal of Nanomedicine. (2008), 3 (4) 471-476. (pdf)
  3. Gongora MC, Lob HE, Landmesser U, Guzik T, Martin WD, Ozumi K, Wall SM, Wilson DS, Murthy N, Gravanis M, Fukai T, Harrison DG. “Loss of extracellular SOD leads to acute lung damage in the presence of ambient oxygen-A potential mechanism underlying Adult Distress Respiratory Syndrome”. American Journal of Pathology. (2008) 173 (4) 915-926. (pdf)
  4. Cao W, Manicassamy S, Tang H, Kasturi S, Pirani A, Murthy N, Pulendran B. “Toll-like receptor mediated type I interferon induction in plasmacytoid dendritic cells requires the rapamycin-sensitive PI3K-mTOR-p70S6K pathway”. Nature Immunology. (2008), 9 (10), 1157-1164. (pdf)
  5. Yang SC, Bhide M, Crispe IN, Pierce RH, Murthy N. “Polyketal Copolymers: A new acid-sensitive delivery vehicle for treating acute inflammatory diseases”. Bioconj Chem. (2008), 19 (6), 1164-1169. (pdf)
  6. Sullivan S, Murthy N, Prausnitz M. “Minimally invasive protein delivery with rapidly dissolving polymer microneedles”. Advanced Materials. (2008), 20(5), 933-938. (pdf)
  7. Chung IM, Enemchukwu NO, Khaja SD, Murthy N, Mantalaris A, Garcia AJ. “Bioadhesive hydrogel microenvironments to modulate epithelial morphogenesis”. Biomaterials. (2008), 29(17), 2637-2645. (pdf)

 

2007

  1. Lee D, Khaja S, Velasquez CJ, Dasari M, Sun C, Petros J, Taylor W, Murthy N. “In vivo imaging of hydrogen peroxide with chemiluminescent nanoparticles”. Nature Materials. (2007), 6(10), 765-769. (pdf)
  2. Lee S, Murthy N. “Targeted delivery of catalase and superoxide dismutase to macrophages using folate”.Biochemical and Biophysical Research Communications. (2007), 360(1), 275-279. (pdf)
  3. Khaja S, Lee S, and Murthy N. “Acid degradable protein delivery vehicles based on metathesis chemistry”.Biomacromolecules. (2007), 8(5), 1391-1395. (pdf)
  4. Lee S, Yang SC, Heffernan MJ, Taylor WR, Murthy N. “Polyketal microparticles: a new delivery vehicle for superoxide dismutase”. Bioconj. Chem. (2007), 18(1) 4-7. (pdf)

 

2006

  1. Talsma S, Babensee J, Murthy N, Wiliams R. “Development and in vitro validation of a targeted delivery vehicle for DNA vaccines”. J. Control. Release. (2006), 112(2), 271-279. (pdf)
  2. Hao J, Kwissa M, Pulendran B, Murthy N. “Peptide crosslinked micelles: A new strategy for the design and synthesis of peptide vaccines”. International Journal of Nanomedicine. (2006), (1), 97-103. (pdf)

 

2005

  1. Heffernan M, Murthy N. “Polyketal nanoparticles: A new pH sensitive, biodegradable drug delivery vehicle”. Bioconj. Chem. (2005), 16(6), 1340-1342. (pdf)

 

Pre-2005

  1. Standley SM, Kwon YJ, Murthy N, Kunisawa J, Shastri N, Guillaudeu SJ, Lau L, Fréchet JMJ. “Acid-degradable particles for protein-based vaccines: Enhanced survival rate for tumor-challenged mice using ovalbumin model”.Bioconj. Chem. (2004), 15(6), 1281-1288.
  2. Goh SL, Murthy N, Xu M, Fréchet JMJ. “Cross-linked microparticles as carriers for the delivery of plasmid DNA for vaccine development”. Bioconj. Chem. (2004), 15(3), 467-474.
  3. Bulmus V, Woodward M, Lianne L, Murthy N, Stayton P, Hoffman A. “A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs”. J. Control. Release. (2003), 93(2), 105-120.
  4. Murthy N, Xu M, Schuck S, Kunisawa J, Shastri N, Fréchet JMJ. “A new delivery vehicle for protein based vaccines: Acid degradable protein loaded microgels”. Proc. Natl. Acad. Sci. (2003), 100(9), 4995-5000.
  5. Murthy N, Campbell J, Fausto N, Hoffman AS, Stayton PS. “Bioinspired pH-responsive polymers for the intracellular delivery of biomolecular drugs”. Bioconj. Chem. (2003), 14(2), 412-419.
  6. Murthy N, Campbell J, Fausto N, Hoffman A, Stayton S. “pH responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides”. J. Control. Release. (2003), 89(3), 365-374.
  7. Murthy N, Thng Y, Schuck S, Xu M, Fréchet JMJ. “A novel strategy for encapsulation and release of proteins: hydrogels and microgels with acid-labile acetal crosslinkers”. J. Am. Chem. Soc. (2002), 124(42), 12398-12399.
  8. Kyriakides TR, Cheung C, Murthy N, Bornstein P, Stayton PS, Hoffman AS. “pH-sensitive polymers that enhance intracellular drug delivery in vivo”. J. Control. Release. (2002), 78(1-3), 295-303.
  9. Hoffman AS, Stayton PS, Press O, Murthy N, Lackey AC, Cheung C, Black F, Campbell J, Fausto N, Kyriakides TR, Bornstein P. “Design of smart polymers that can direct intracellular drug delivery. Polymers for Advanced Technologies. (2002), 13(10-12), 992-999.
  10. Cheung C, Murthy N, Stayton P, Hoffman A. “A pH-sensitive polymer that enhances cationic lipid-mediated gene transfer”. Bioconj. Chem. (2001), 12(6), 906-91.
  11. Hoffman AS, Stayton PS, Press O, Murthy N, Lackey C, Cheung C, Black F, Campbell J, Fausto N, Kyriakides TR, Bornstein P. “Bio-inspired polymers that control intracellular drug delivery”. Biotechnol. Bioprocess. Eng. (2001), 6(4), 205-212.
  12. Murthy N, Chang I, Stayton P, Hoffman A. “pH-sensitive hemolysis by random copolymers of alkyl acrylates and acrylic acid”. Macromol Symp. (2001), 172(1) (Polymers in Medicine), 49-55.
  13. Mourad PD, Murthy N, Porter T, Poliachik SL, Crum L, Hoffman AS, Stayton PS. “Focused ultrasound and poly(2-ethylacrylic acid) act synergistically to disrupt lipid bilayers in vitro”. Macromolecules. (2001), 34(8), 2400-2401.
  14. Stayton PS, Hoffman AS, Murthy N, Lackey C, Cheung C, Tan P, Klumb LA, Chilkoti A, Wilbur FS, Press OW. “Molecular engineering of proteins and polymers for targeting and intracellular delivery of therapeutics”. J. Control. Release. (2000), 65(1-2), 203-220.
  15. Murthy N, Robichaud J, Tirrell DA, Stayton PS, Hoffman AS. “The design and synthesis of polymers for eukaryotic membrane disruption”. J. Control. Release. (1999), 61(1-2), 137-143.
  16. Lackey C, Murthy N, Press OW, Tirrell DA, Hoffman AS, Stayton PS. “Hemolytic activity of pH-responsive polymer-streptavidin bioconjugates”. Bioconj. Chem. (1999), 10(3), 401-405.
  17. Murthy N, Subramanian U, Anant S, Subramanian KN. “The replication inhibition activity of the WT1 tumor suppressor protein resides in its N-terminal 298 amino acid region, and does not require specific binding of the protein to the replication origin sequence”. Int. J. Oncol. (1998), 13(6), 1275-1280.